Stem Cell Therapy for Diabetic Nephropathy

Diabetic Nephropathy, as we know, is a secondary kidney disorder which is caused by long time diabetes. The typical symptom of diabetes is high blood sugar or blood glucose. If it lasts long, the density of blood will lead to blocking in micro-blood circulation firstly. And sclerosis takes place. With time passing by, further damage appears such as kidney disease. As for the treatment of diabetic nephropathy, we should both treat diabetes and diabetic nephropathy.
Firstly, we focus on the treatment of diabetes. To treat some disease, figuring the pathological mechanism is important. About 50% to 70% of patients with type 1 diabetes are connected with immune disease. In normal condition, our body can recognize and utilize insulin. Insulin has function of using blood sugar; however, when our immune system goes wrong, our body will be failed in recognizing and utilizing insulin. When insulin secreted by pancreas islet can not display their sugar-lowering function, blood sugar accumulates in our body and finally, leading to the increase of blood sugar level. Therefore, on the basis of above theory, to relieve or control this condition, we need to regulate immune system, which will enable our body to recognize and use insulin.
Stem cells can be used to treat diabetes. Firstly, stem cells have a strong ability of generating and differentiating, which means that it can generate into a large amount of pancreatic B cell and solve the problem that the patients’ body is short of islet cells. Secondly, the islet cells generated by stem cells can adjust the blood sugar. Thirdly, stem cell transplant can prevent the complication of Diabetes, and treat Diabetes fundamentally.
In addition, stem cell can also be used to treat kidney disorder which is caused by diabetes. Usually, before it is applied in clinic, Chinese Medicine is used to create a favorable environment by dilating blood vessels, anti-inflammation, anti-coagulation and degradation of the immune complex.