Pediatric Nephrotic Syndrome from Simple to Complex

90% of Nephrotic Syndrome patients are children, so there appears a term called Pediatric Nephrotic Syndrome. Pediatric Nephrotic Syndrome is mostly primary one, the main pathological change is the increased permeability of renal glomerular basilar filtration membrane. The manifestations in clinic are a large amount of proteinuria, which is more than 3.5g per 24 hours, hypoproteinemia, the protein in the plasma is less than 30g/L, edema and hyperlipidaemia.
Why does Pediatric Nephrotic Syndrom develop from the simple to the Complex? When it comes to this, we should start from the treatment, the recurrence, and the complications.
1. The treatment for Pediatric Nephrotic Syndrome in most countries is the application of hormone. Long time application of hormone can lead to the reliance of hormone, thus making Pediatric Nephrotic Syndrome into refractory one, which is more difficult to treat. Refractory Nephrotic Syndrome is one indication of renal biopsy, which can give a confirmed diagnosis for the pathological type, the degree of kidney lesion, as well as supply instruction of medication. In the period of using hormone, children may have pain in the back, which is accompanied by hematuria, increased high blood pressure, severer edema or declined renal function, indicating the deterioration of renal function and the forming of thrombosis.
2. Recurrence is also a factor which can make the Pediatric Nephrotic Syndrome from the simple one to the complex one. In most of the time, recurrence happens as a result of infection. And the infection can be divided into the following cases: firstly, the insufficiency of immune function of cells and the complement system can lead to recurrence. Secondly, long time using of immunosuppressive agent and cortical hormone can also lead to the recurrence of Pediatric Nephrotic Syndrome much easiler. Thirdly, fluid immune function decline is also a factor. Last but not least, malnutrition of protein, edema can also lead to the partial circulation barrier, thus causing edema
3. The complication is also an important factor which can make Pediatric Nephrotic Syndrome from the simple one to the complex one.It is the main reason why children with Pediatric Nephrotic Syndrome die.
From the above, we can get a conclusion that Pediatric Nephrotic Syndrome can develop from the simple one to the complex one. And among them, treatment measure plays a critical role in it. Compared with hormone and immunosuppressive agent, Chinese Medicine can treat Pediatric Nephrotic Syndrome fundamentally,for it can repair the damaged intrinsic cells as well as increase the immune ability.