Kidney damage people's health has been a major killer, to the lives of patients with serious implications. Diabetic nephropathy is one of them, it appears with the following factors are closely linked, a detailed understanding of them under.
Genetic factors
Diabetic nephropathy showed family aggregation, family history of hypertension in some patients with diabetes, the incidence of diabetic nephropathy was significantly higher than in patients without family history of hypertension. In addition, inter-ethnic incidence of diabetic nephropathy there are differences.
Hypertension
Hypertension and diabetic nephropathy is not directly related, but the course of pre-existing hypertension or microalbuminuria to elevated blood pressure can accelerate the progress of diabetic nephropathy after and deterioration of renal function, increased urinary albumin excretion.
Hyperglycemia
Diabetic nephropathy is closely related with high blood sugar, high blood sugar and glycation endproducts increase induced mesangial cell proliferation, extracellular matrix increased mesangial expansion, glomerular basement membrane thickening, good blood glucose control can significantly delaying its development.
Renal hemodynamic abnormalities
Glomerular basement membrane collagen Ⅳ messenger sugar nucleic acid increased, the basement membrane thickening, and ultimately the formation of mesangial diffuse, nodular lesions, occurred glomerulosclerosis. As the disease progresses, can occur in diabetic nephropathy.
In the case of increased pressure, increased protein filtration may also deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and can cause nodular and diffuse glomerulosclerosis, with development of the disease, diabetic nephropathy can occur.
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