Stem Cell Therapy for Lupus Nephritis

Systemic Lupus Erythematosus, which can be called SLE for short, is a kind of anto-immune disease. It is also called Lupus Nephritis. If human body is infected by lupus factor, abnormal immune reaction will keep existing, causing pathogenic autoantibody forming in body. Then, large quantity of immune complex, such as IgG or IgM, will accumulate in blood, thus depositing in glomeruli capillary epithelial cells area. Gradually, kidney damaged will be caused, and symptom of proteinuria will also appear. In addition, patients also feel headache for it recurs easily and frequently. So effective treatment is critical.
How to treat? From the above, it can also be easily found that the most effective method to treat the disease is to remove immune complex in blood and stop the formation of immune complex as well as repair the damage caused by immune complex accumulation. Based on this, Stem Cell Treatment have gained more and more attention from Lupus Nephritis patients.
Firstly, stem cell can regenerate into many capillary endothelial cells and repair the damaged renal membrane, repair the filtration membrane, improve the filtration function, thus improving the renal glomerular filtration.
Secondly, stem cell can also generate into munologic balance cells such as Ts cells, Th cells, etc. Stem cell can also balance the immunoreaction, diminish a variety of factors which can cause renal glomerular disease, avoid the continuous damage to renal tubules, prevent it from developing into renal failure.
This is only the ideal therapy. Why? To achieve this, we must create a cleaner inner environment for the stem cell transplant. In our Hospital, we have researched out immunotherapy accordingly, which can be divided into 6 steps: scientific diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
Through immune diagnosis, we can know the type of immune response and the place where the immune complex deposit. Through immune clearance, we can clear away the immune complex which is in blood, thus decreasing the damage it causes. Through immune inhibition, we can stop the excessive immune response for the time being, thus stopping the damage to the normal cells in the kidney as well. Through immune adjustment, we can clear away the immune complex which deposit onto the kidney with medicines. Through immune protection, we use stem cells and so on, which can increase the immunity repair the damaged intrinsic cells, thus reviving renal function.