Creatinine Level Rises again after Kidney Transplant in Diabetes

In the end stage of diabetes ( diabetic nephropathy or diabetic kidney disease), some patients take kidney transplant for their own kidneys fail to work. It really changed the condition and patients can feel better. However, some years later, they find out that creatinine in serum rises again, which makes them confused what to do next.
To solve this problem, firstly, let’s figure out the reason why diabetes comes into being. The pathology of Diabetes type 1 is absolutely inadequate secretion of insulin due to the damage to islet cells. The causes of it include hereditary factor and environment factor which cause immune disorder. The abormal immune response will cause damage to islet cells. In contrast, type 2 diabetes is caused by the relatively insufficiency of insulin secretion. No matter which kind of diabetes, we should repair the damaged beta cells or differentiate beta cells so that insulin can be secreted normally. Only after insulin is enough, blood sugar can be transformed into energy, or else, there will be high blood sugar, which will damage kidney if it lasts for a long time. After kidney is damaged, creatinine will rise accordingly for filtrating creatinine is the work of kidneys.
However, kidney transplant can not solve this problem. How to solve the above-mentioned problem? Stem cells can solve this problem. Stem cells are the most primary cells of the human body. After transfused into the patients' body, these stem cells can differentiate into various functional cells needed. The stem cells can differentiate into new islet cells and replace the dead ones, thus recovering the islet function. T-reg cells can help regulate the immune system and stop the attack to healthy islet cells, thus protecting the remaining islet function.