Immunopathogenesis of Idiopathic Nephrotic Syndrome

Idiopathic Nephrotic Syndrome is a kind of Nephrotic Syndrome, which takes place in some babies. Usually, symptoms of Idiopathic Nephrotic Syndrome appear three to six months after they are born. It also has four characteristics of Idiopathic Nephrotic Syndrome such as a large amount of protein in urine, which is more than 3.5g per 24 hours, low proteinuria, the albumin in the plasma is less than 3g /L, edema or swelling, hyperlipidaemia.
Types of Nephrotic Syndrome
To understand the Idiopathic Nephrotic Syndrome and distinguish it from other types of Nephrotic Syndrome such as Lupus Nephritis, it is necessary to make a classification here.
1. primary Nephrotic Syndrome
Primary Nephrotic Syndrome is a kind of kidney disease which is caused by the damage of kidney itself, which accounts for more than 90% of all the Nephrotic Syndrome.
2. Secondary Nephrotic Syndrome
Secondary Nephrotic Syndrome is caused by other factors such as lupus, purpura, and so on. The manifestations are such as Purpura Nephritis, Lupus Nephritis, and so on.
3. Idiopathic Nephrotic Syndrome
Idiopathic Nephrotic Syndrome is always related to the genetic factors.
Pathological reasons
1. immune response
As we mentioned in the premier articles, most kidney diseases are caused by disorder of immune response. The deposition of immune complex leads to symptoms.
2. inflammatory response
pathological factors such as virus and bacteria from outside invades kidney, leading to inflammatory reaction. In this case, the permeability of renal glomerular filtration is damaged, thus causing a series of protein leaking out.
The prognosis of Idiopathic Nephrotic Syndrome is bad. Some baby aging 6 months to 1 year die from infection. Some aging from 2 to 3 years old die from uremia. So some people take kidney transplant after they are 2 years old.
Treatment
In our hospital, after years of trial and error, and after bring in the most advanced technology in the kidney treatment in the world, the experts researched out a new therapy which is called immune therapy. It can be divided into 6 steps: scientific diagnosis, immune inhibition with brand new medicine, immune tolerance, immune adjustment with stem cell and Chinese Medicine, immune protection and immune clearance.